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Biography

ข้อมูลภาษาไทย

Education and Work Experiences

  • 2017-present Associate of the Abdus Salam international centre for theoretical physics (ICTP), Trieste, Italy.
  • 2015-present  Assistant Professor, Department of Physics, Kasetsart University, Thailand.
  • 2005-present  Lecturer, Department of Physics, Kasetsart University, Thailand.
  • 1999-2005      Ph.D. in Physics with Prof. Klaus Schulten, University of Illinois at Urbana-Champaign, Illinois, USA.
  • 1995-1999      M.Phys. (Hons.) in Physics, University of Oxford, Oxford, UK.
  • 1994-1995      A-Level (High School), New College, Cardiff, Wales, UK.

 

Honours and Awards

  • 2017-2022    Regular associate of the Abdus Salam international centre for theoretical physics (ICTP), Trieste, Italy. 
  • 2014-2015    Best KU physics teacher  (voted by 4th year physics students).

 

Research Interests

I have been fascinated by the nanophysical aspect of molecular biology. Personally, I think molecular biology is the future of nanophysics and nanotechnology. I have been amazed by learning how biomolecules manage to manipulate atoms and molecules at nanoscale. So I really would like to understand how they manage to do it. My research interests lie in the theoretical and computational aspects of molecular biophysics. By working closely with experimentalists, I use physics and computers to study and understand these nano-biomolecular machines such as proteins. My current research topics and interests are

  • Ion conduction and pore formation by bacterial protein toxins
  • Behaviours of water molecules around protein and membrane environment
  • Cytoskeletal polymerization of actin and actin like proteins
  • Proton transfer and hydrogen bonded network in biology
  • Rotary mechanism and proton transport in biomolecular motors such as ATP synthase and Flagellar
  • Calcium-dependent membrane binding proteins (Annexin A5)

Our biophysics lab is lacated at room 451, 4th floor,  physical science (Sci 45 years) building. We share the lab space with the computational meterial physics group.

Publications and Books

Most of my published works are on bacterial toxins. However, recently my research interests have been extended into braoader topics such as water dynamics and cytoskeletal proteins.

2022

1. Thamwiriyasati, N., Kanchanawarin, C., Imtong, C., Chen, C., Li, H., Angsuthanasombat, C. (2022) Complete structure elucidation of a functional form of the Bacillus thuringiensis Cry4Ba delta-endotoxin: Insights into toxin-induced transmembrane pore architecture, BBRC, 620, p.158-164. [IF=3.322]

 

2017

  1. Kurehong, C., Kanchanawarin, C., Powthongchin, B., Prangkia P., Katzenmeier, G., and Angsuthanasombat, C. (2017) Functional Contributions of Positive Charges in the Pore-Lining Helix 3 of the Bordetella pertussis CyaA-Hymolysin to Hemolytic Activity and In Channel Opening, Toxins, 9(3), 109. [IF=3.571]
  2.  Kanchanawarin, C. , and Angsuthanasombat, C. a chapter in the book "Computational design of chemicals for the control of mosquitoes and their diseases" by James Devillers (ed), CRC Press, 2017.

2015

  1. Kurehong, C., Kanchanawarin, C., Powthongchin, B., Katzenmeier, G., and Angsuthanasombat, C. (2015) Membrane-pore formation characteristics of the Bordetella pertussis CyaA-Hymolysin Domain, Toxins, 7(5) p1486-96. [IF=2.94]
  2. Sriwimol, W. Aroonkesorn, A.Sakdee, S., Kanchanawarin, C. Uchihashi, T., Ando, T., and Angsuthanasombat, C. (2015) Potential Pre-pore Trimer Formation by the Bacillus thuringiensis Mosquito-Specific Toxin: Molecular Insights into a Critical Prerequisite of Membrane-Bound Monomers, JBC, 290, p.20793-803. [IF=4.57]

2014

  1. Imtong, C., Kanchanawarin, C., Katzenmeier, G., and Angsuthanasombat, C. (2014) Bacillusthuringiensis Cry4Aa insecticidal protein: functional importance of intrinsic stability of the unqique α4–α5 loop comprising the Pro-rich sequence. BBA Proteins and Proteomics, 1844(6), p.1111-8. [IF=2.75]
  2. Juntadech, T., Kanintronkul, C., Kanchanawarin, C., Katzenmeier, G.,  and Angsuthanasombat, C. (2014). Importance of polarity of the α4–α5 loop residue - Asn166 in the pore-forming domain of the Bacillus thuringiensis Cry4Ba toxin: Implication for ion premeation and pore opening. BBA Biomembranes, 1838(1), p.319-327. [IF=3.84]

2013

  1. Srikongrug, S, and Kanchanawarin C.  (2013)  The study of structure and dynamics of water molecules around phospholipid bilayer using molecular dynamics methods. Siam Physics Congress 2013 Proceedings.

2010

  1. Taveecharoenkool, T, Angsuthanasombat C, Kanchanawarin C.  (2010)  Combined molecular dynamics and continuum solvent studies of the pre-pore Cry4Aa trimer suggest its stability in solution and how it may form pore. PMC Biophysics (now called BMC Biophysics). 3(10). [IF=2.89]

 

Teaching

Personally, I enjoy teaching physics and I have always been looking for ways to improve it. Many times, these teaching helps me in doing my biophysics research. I have been teaching the following classes

Undergraduate Classes

Graduate Clasess

 

For more info about my research please see My Research Group Page